Bone graft stabilisation with an osseointegrated implant retained prosthesis

The intricacies of cleft lip and palate treatment are numerous. A case is reported where a problematic alveolar bone graft was finally stabilized by loading the bone with an osseointegrated implant-retained prosthesis. The reasons for failure of the previous grafts are discussed and the importance of a team approach to patient care highlighted.peer-reviewe

INFORMATION, ENERGY, AND EVOLUTION

Within the current theory of evolution, the development in the direction of higher complexity is taken to be a necessary condition. This gives birth to a problem why this direction is prevalent for evolution. Philosophers and scientists tried to substantiate this condition and to explain it, yet the question still remains open. Our aim is to find specific regularities in nature that make complexity the chosen direction. Three main causes for this direction are deduced from initial principles, assuming that information and energy are the vital nutrients for evolution. Consequently, we base our explication and explanation of causes on the principles of information theory, Ashby’s principle of requisite variety/complexity, as well as we suggest and ground some additional principles of the system development. This makes possible to separate three principal stages for evolution of living organisms: biological, neurological, and epistemological

Aid, Public Sector Fiscal Behaviour and Developing Country Debt

aid, borrowing, debt, fiscal behaviour

Monetary Policy, Business Cycles and the Behavior of Small Manufacturing Firms

We present evidence on the cyclical behavior of small versus large manufacturing firms, and on the response of the two classes of firms to monetary policy. Our goal is to take a step toward quantifying the role of credit market imperfections in the business cycle and in the monetary transmission mechanism. We find that, following tight money, small firms sales decline at a faster pace than large firm sales for a period of more than two years. Further, bank lending to small firms contracts, while it actually rises for large firms. Monetary policy indicators tied to the performance of banking, such as M2, have relatively greater predictive power for small firms than for large. Finally, small firms are more sensitive than are large to lagged movements in GNP. Considering that small firms overall are a non-trivial component of the economy, we interpret these results as suggestive of the macroeconomic relevance of credit market imperfections.

Aid and Public Sector Fiscal Behaviour in Failing States

This paper looks at interactions between foreign aid and the public sector in developing countries, especially those considered to be fragile or failing states. A model is proposed which employs actual budgetary appropriations and revenue estimates (rather than estimated target variables) and allows for asymmetric preference. Variants of the model are estimated using time-series data for Papua New Guinea (PNG). PNG is classified as a fragile state by the international community owing to perceived policy and institutional inadequacies. Results obtained suggest that foreign aid increases consumption and investment expenditures and decreases tax revenues and the level of borrowing.Foreign aid, taxes, public spending, fungibility, fragile states, failing states, Papua New Guinea

Aid and Growth in Fragile States

The literature on aid has come a long way in recent years, and as a result we now know much more about aid effectiveness than possibly ever before. But significant gaps in knowledge remain. One such gap is the effectiveness of aid in the so-called ?fragile states?, countries with critically low policy and institutional performance ratings. The current paper addresses this void by examining possible links between aid and economic growth in fragile states. It finds that: (i) growth would have been 1.4 percentage points lower in highly fragile states in the absence of aid to them, compared to 2.5 percentage points in other countries; (ii) highly fragile states from a per capita income growth perspective can only efficiently absorb approximately one-third of the amounts of aid that other countries can, and; (iii) while from the same perspective most fragile states are under-aided, to the extent that they could efficiently absorb greater amounts of aid than they currently receive, many of the highly fragile states are substantially over-aided in this sense. The overall conclusion is that donors need to look very closely at their aid to the sub-set of fragile states deemed in this paper as highly fragile.foreign aid, economic growth, fragile states, policies, absorptive capacity

Specific isoforms of translation initiation factor 4GI show differences in translational activity

The eukaryotic initiation factor (eIF) 4GI gene locus (eIF4GI) contains three identified promoters, generating alternately spliced mRNAs, yielding a total of five eIF4GI protein isoforms. Although eIF4GI plays a critical role in mRNA recruitment to the ribosomes, little is known about the functions of the different isoforms, their partner binding capacities, or the role of the homolog, eIF4GII, in translation initiation. To directly address this, we have used short interfering RNAs (siRNAs) expressed from DNA vectors to silence the expression of eIF4GI in HeLa cells. Here we show that reduced levels of specific mRNA and eIF4GI isoforms in HeLa cells promoted aberrant morphology and a partial inhibition of translation. The latter reflected dephosphorylation of 4E-BP1 and decreased eIF4F complex levels, with no change in eIF2 alpha phosphorylation. Expression of siRNA-resistant Myc-tagged eIF4GI isoforms has allowed us to show that the different isoforms exhibit significant differences in their ability to restore translation rates. Here we quantify the efficiency of eIF4GI promoter usage in mammalian cells and demonstrate that even though the longest isoform of eIF4GI (eIF4GIf) was relatively poorly expressed when reintroduced, it was more efficient at promoting the translation of cellular mRNAs than the more highly expressed shorter isoforms used in previous functional studies